Resistance of Mice to Infection with Friend Disease Virus After Subcutaneous Injection of Friend Virus and Friend Spleen Cells
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چکیده
منابع مشابه
Resistance of mice to infection with Friend disease virus after subcutaneous injection of Friend virus and Friend spleen cells.
Swiss mice injected subcutaneously with suspensions of spleen cells or an extract of spleens from mice infected with Friend virus develop resistance to subsequent intravenous inoculation of Friend virus. A single injection of either Friend virus or Friend cells induces resistance. Immunized mice display resistance when challenged 6 months after immunization and survive for at least 20 weeks aft...
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Proliferation and erythroid differentiation of transplanted DBA/2 marrow cells and Friend virus-induced leukemic cells were assessed in syngeneic, allogeneic (H-2 compatible), and (BALB/c x DBA/2)F(1) hybrid mice (CDF(1)). Measurements were made 5 days after transplantation of donor cells into nonirradiated or X-irradiated mice by the spleen colony or the (125)IUdR-(59)Fe uptake methods. Growth...
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Possibleassociationshave been soughtbetween cell surface Friend murine erythroleukemia virus (FV)-en codedmoleculesandH-2 moleculesby subjectingspleen cells from infected mice to antibody-inducedcappingof one moleculeand then examiningthe cells for cocapping of the second.Cappingwas detectedbythe resistanceof capped cells to lysis by the capping antiserum and com plement. Three strains of mice ...
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Resistance to malignant erythropoiesis induced by Friend spleen focus-forming virus and resistance to marrow stem cell allografts are under genetic control. Strains of mice, e.g., C57BL/6 and B10.D2, which are homozygous for resistance at the Fv-2 locus, are also good rejectors of most bone marrow allografts. (89)Sr, a bone-seeking isotope, irradiates marrow but not other lymphoid organs and ab...
متن کاملInduction of the early stages of Friend erythroleukemia with helper-free Friend spleen focus-forming virus.
The polycythemia-inducing strain of Friend virus (FV-P) causes a multistage erythroleukemia in susceptible mice. FV-P is a complex of two viruses, a replication-competent virus [Friend murine leukemia virus (F-MuLV)] and a replication-defective spleen focus-forming virus (SFFVp). We have addressed directly the role of SFFVp in the induction of the early stages of Friend disease by constructing ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1973
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.8.5.708-714.1973